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Other side effects include signs of being in heat, including vaginal discharge or spotting, infection of the uterus in intact female dogs (pyometra), cystic endometrial hyperplasia and other abnormalities of the reproductive system, diarrhea, vomiting, lack of energy,。

Diethylstilbestrol (DES) has only one primary use: the treatment of sphincter tone incontinence in female dogs. DES is used at extremely low doses thus avoiding any toxicity。

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